Versatile New Lanthanide Complexes Containing Organic Ligand Derived From Vitamin B6 as Potential Tyrosinase Inhibitors: Synthesis, Characterizations, and Structure Activity Investigations

ABSTRACT The synthesis, characterizations, and tyrosinase enzyme inhibition experiments on eight novel lanthanide metal complexes ( 1 – 8 ) are reported. A multidonor versatile ligand L was prepared from the condensation reaction of picolinohydrazide with pyridoxal. The synthesized complexes were analyzed using FT‐IR and UV‐vis spectroscopies, elemental (CHN) analysis, and single‐crystal X‐ray diffraction analysis. These complexes exhibited significant tyrosinase enzyme inhibition with IC 50 values in the range of 9.67 ± 0.17–21.88 ± 0.57 μM. The molecular docking results of the most active complex ( 2 ) correlate well with in vitro observations.