神经保护
创伤性脑损伤
神经干细胞
医学
再生(生物学)
内斯汀
病变
内生
神经再生
神经科学
脑损伤
药理学
干细胞
内科学
病理
生物
细胞生物学
精神科
作者
Min Sun,Austin P. Passaro,Charles-Francois V. Latchoumane,Samantha Spellicy,Michael Bowler,Morgan Goeden,William J. Martin,Philip V. Holmes,Steven L. Stice,Lohitash Karumbaiah
标识
DOI:10.1089/neu.2019.6443
摘要
The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy for neural injuries is currently lacking. We hypothesized that NSC-derived extracellular vesicles (NSC EVs) mediate repair indirectly after TBI by enhancing neuroprotection and therapeutic efficacy of endogenous NSCs. We evaluated the short-term effects of acute intravenous injections of NSC EVs immediately following a rat TBI. Male NSC EV-treated rats demonstrated significantly reduced lesion sizes, enhanced presence of endogenous NSCs, and attenuated motor function impairments 4 weeks post-TBI, when compared with vehicle- and TBI-only male controls. Although statistically not significant, we observed a therapeutic effect of NSC EVs on brain lesion volume, nestin expression, and behavioral recovery in female subjects. Our study demonstrates the neuroprotective and functional benefits of NSC EVs for treating TBI and points to gender-dependent effects on treatment outcomes, which requires further investigation.
科研通智能强力驱动
Strongly Powered by AbleSci AI