细胞激素风暴
2019年冠状病毒病(COVID-19)
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019-20冠状病毒爆发
冠状病毒
倍他科诺病毒
免疫系统
生物
病毒学
免疫学
表位
抗体
炎症
严重急性呼吸综合征冠状病毒
细胞因子
抗原
医学
爆发
疾病
病理
传染病(医学专业)
标识
DOI:10.1016/j.micinf.2020.02.006
摘要
One of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.
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