In hypophysectomized females, Rana esculenta, a significant uptake of labeled ovine FSH and LH was evident in both the ovary and oviduct. This binding was specific only for the ovary. Ovariectomy did not modify the affinity of the oviduct for these gonadotropins. The possibility of the presence of discrete receptor molecules for FSH and LH in the ovary of Rana esculenta is discussed.