Antiinflammatory Mechanism of the Louicera japonica Thunb. Extract

OBJECTIVE:To investigate the anti-inflammatory mechanism of the Lonicera japonica Thunb.extract(LTE).METHODS:The changes in the levels of MDA,PGE2,Histamine and 5-HT in exudantes of paw edema induced by carrageenan in rats were detected using biochemical analysis;and the weight of adrenal gland and the content of Vitamin C in adrenal gland in normal mice were measured as well.RESULTS:The results showed that after intragastric administration for 5 consecutive days,LTE(2.5,5,and 10g· kg-1) markedly inhibited the hindpaw edema and decreased the levels of MDA,PGE2,Histamine and 5-HT in exudantes of paw edema induced by carrageenan in rats.However,LTE(at different dose) has no effect on the weight of adrenal and the content of Vitamin C in normal mice.CONCLUSION:By means of inhibiting the production or release of the local inflammatory factors,LTE has the anti-inflammtory effect,which is similar to that of the nonsteroidal anti-inflammatory drugs.