EXPERIMENTAL ANIMAL MYOCARDITIS MODEL: COXSACKIEVIRUS B3 MYOCARDITIS IN BALB/C MICE

Aim To establish an experimental animal myocarditis model.Methods BALB/c mice were inoculated intraperitoneally with coxsackievirus B3.Results Severe myocarditis was caused.Yellowish white patches were seen on the surface of the right ventricle of the hart from the 4 th to the 33 rd day after challenged.On the 4 th day,myocardial fibres appeared fragmented,and inflammatory cells were sparse;then,morphonuclear leukocytes and lymphcytes infilleated increased,and reached to the peak 14 days after infection;in this stage,the mortality was higher.After the 14 th day,the inflammatory infiltration decreased gradually,fibrosis can be observed.Conclusion This animal myocarditis model can be used in the research of nature course of myocarditis,the sequela,and the effect and mechanism of certain drugs used in myocarditis therapy.