Rhabdomyolysis in a young adult following chronic non-prescribed pregabalin use

Rhabdomyolysis is a serious condition caused by skeletal muscle breakdown and can present with severe generalised pain, elevated creatine kinase and myoglobinuria. We report a rare case of rhabdomyolysis likely induced by chronic pregabalin abuse (15-year history of non-prescribed use) in a physically active man in his 20s. Despite the absence of trauma, infection or other known causes, he presented with typical symptoms and laboratory findings of rhabdomyolysis. He improved significantly with supportive care, including intravenous fluids and analgesia, and was discharged after stabilisation. This case highlights the importance of considering pregabalin as a potential myotoxic agent—even without overdose—particularly in young patients with unexplained muscle pain. Careful monitoring of drug history and early recognition are essential to prevent complications such as acute kidney injury and to ensure full recovery.