ZnFe(PBA)@Ti3C2Tx nanohybrid-based highly sensitive non-enzymatic electrochemical sensor for the detection of glucose in human sweat

The ZnFe prussian blue analogue [ZnFe(PBA)] was infused with Ti₃C₂T_x (MXene) denoted as ZnFe(PBA)@Ti₃C₂T_x and was prepared by an in-situ sonication method to use as a non-enzymatic screen printed electrode sensor. The advantage of non-enzymatic sensors is their excellent sensitivity, rapid detection, low cost and simple design. The synthesized ZnFe(PBA)@Ti₃C₂T_x was characterized for its physical and chemical characterization by XRD, Raman, XPS, EDAX, and FESEM analysis. It possessed multiple functionalized layers and a cubic structure in the nanohybrid. Further, the sensor was investigated by using electroanalytical studies such as cyclic voltammetry and chronoamperometry analysis. The enhanced surface area with a cubic structure of ZnFe(PBA) and the excellent electrical response of Ti₃C₂ nanosheet support the advancement of a non-enzymatic electrochemical glucose sensor with improved sensitivity of 973.42 µA mM^-1 cm^-2 with the limit of detection (LOD) of 3.036 µM (S/N = 3) and linear detection range (LDR) from 0.01 to 1 mM.