LB1748 Cannabidiol inhibits lipogenesis by regulating Akt/AMPK-SREBP-1 pathway in sebocytes

Cannabidiol (CBD) is known to relieve pain, stress and inflammation. Acne is one of the most common skin diseases. The pathophysiology of acne involves not only genetic and environmental factors, but also other factors including hyperseborrhea, over keratinization of follicular keratinocytes and overgrowth of C. acnes. Side effect of topical acne therapeutic include skin irritation, erythema and dry skin. Therefore, there are actively making an attempt for less side effects, and effective treatment in acne therapy.