Mesoporous Frameworks Constructed by Endogenous Species to Promote the Efficient Healing of Infected Wounds

Abstract Long‐term efforts are made to construct biocompatible nanomedicine carriers. Herein, Fe‐based hierarchically mesoporous MIL‐88A (HMMIL‐88A) is deliberately fabricated from endogenous species using a soft‐template strategy. The resultant mesoporous frameworks presented an adjustable mesopore size and controllable elliptical nanomorphology, ideally meeting the needs of biomedical applications. Such an open mesoporous structure made the inherent metal sites more accessible, significantly enhancing their peroxidase (POD)‐like catalytic activity, while providing sufficient space for biogenic guest loading. On this basis, a therapeutic platform is designed for efficient chronic wound healing by encapsulating lysozyme (LYZ) and copper glycyl‐histidine‐tripeptide (GHK‐Cu) as guests and slowly released therapeutic agents. The synergistic effect of LYZ and the biomimetic POD‐like activity of HMMIL‐88A resulted in a potent antibacterial efficacy. GHK‐Cu is subsequently delivered into cells by HMMIL‐88A, which promotes the expression of superoxide dismutase 3 and sirtuin 1, thereby protecting the cells from oxidative stress. In vivo studies confirmed that the designed nanoplatform downregulated the TNF‐α signaling pathway to reduce inflammation and upregulated CD31 to promote neovascularization, consequently facilitating wound healing. Such proof‐of‐concept design principle not only implements optimal goals in wound treatments but also affords a basis for the formulation of other nanoplatforms by altering the accommodated biogenic guests.