病态行为
姜黄素
脂多糖
行为绝望测验
药理学
开阔地
肿瘤坏死因子α
炎症
医学
内分泌学
免疫学
内科学
海马体
抗抑郁药
作者
Lúcia Margarete dos Reis,Merelym Ketterym de Oliveira,Viviana Carolina Trujillo Rojas,Tatiane Helena Batista,Elisa S Estevam,Fernando Vitor-Vieira,Fabiana C. Vilela,Alexandre Giusti‐Paiva
标识
DOI:10.1016/j.neulet.2022.136680
摘要
Lipopolysaccharide (LPS) is a potent inducer of inflammation, triggering behavioral changes and fever. The present study aimed to evaluate whether pretreatment with curcumin prevents the behavioral changes and fever induced by LPS through the modulation of nuclear factor-erythroid 2 related factor 2 (Nrf2). Male Wistar rats received either vehicle or LPS and after 2 h, the behavioral responses were assessed through open field test (OFT), social interaction test, forced swim test (FST), and food intake assessment. The febrile response was assessed by telemetry after vehicle or LPS injection to evaluate the effect of curcumin on the thermoregulatory response during the immunological challenge. The pretreatment with curcumin at doses of 50 and 100 mg/kg prevented the reduction of distance traveled on OFT, increased the immobility time of FST, impaired social withdrawal, decreased food intake, and induced fever. In addition, at these doses, it was possible to observe a significant decrease in the plasma levels of cytokines and an increase in Nrf2 translocation to the cell nucleus during the immunological challenge. Our data provide further evidence of curcumin's ability to prevent LPS-induced sickness behavior and fever possibly by a mechanism related to the modulation of Nrf2 translocation.
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