糖尿病性视网膜病变
视网膜
抗氧化剂
医学
MAPK/ERK通路
药理学
内皮
化学
生物化学
信号转导
内分泌学
糖尿病
作者
Velia D’Agata,Agata Grazia D’Amico,Grazia Maugeri,Claudio Bucolo,Silvia Rossi,Salvatore Giunta
标识
DOI:10.1080/10286020.2022.2137022
摘要
Carnosol is a natural compound with antioxidant properties. Based on this evidence, in the present study we investigated whether this compound can protect retinal vascular endothelium from hyperglycemic insult responsible for diabetic retinopathy development. We performed in vitro study on human retinal endothelial cells (HREC) cultured both in normal and high glucose conditions to assess the effects of carnosol on cell viability, Nrf2 expression, HO-1 activity, and ERK1/2 expression. HREC exposed to high glucose insult were treated with carnosol. Data indicated that carnosol treatment is able to induce HO-1 expression via Nrf2 activation and counteracts the damage elicited by high glucose. Further, carnosol activation of Nrf2/HO-1 signaling axis involves ERK1/2 pathway. These data confirm the therapeutic value of carnosol by suggesting its use to treat diabetic retinopathy.
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