Hydroxyl Radicals Unlock Strong C( sp 3 )─Si Bonds: Photocatalytic Alkylation and Silacycle Engineering

Si can be activated and used in radical alkylation under our methodology. Moreover, we show that this strategy can be applied to the radical difunctionalization of silacycles, leading to the synthesis of organosilicon compounds not previously achievable through other methods. We anticipate that this approach will serve as a foundation for the development of more advanced radical reactions with unactivated organosilicon reagents, thereby facilitating the synthesis of a wide range of valuable molecules.