To the Editor: Vulvar lichen sclerosus (VLS) is a chronic, progressive inflammatory dermatosis characterized by loss of vulvar architecture. Patients with VLS have a high risk of comorbid anxiety and depression;1 however, limited data exist on medical comorbidities among patients with VLS. Understanding comorbidities associated with VLS may provide perspectives for comprehensive treatment of affected patients. Therefore, we examined comorbidities and medications among women with VLS from a single-site dermatology center (2019-2021) using a retrospective case-control study.