阳离子聚合
卟啉
抗菌活性
聚合
化学
抗菌剂
单体
烷基
聚合物
溶解度
组合化学
光化学
高分子化学
材料科学
有机化学
细菌
生物
遗传学
作者
Shusu Ren,Xiang Xu,Jingbo Sun,Haitao Zhao,Weiwei He,Lifen Zhang,Zhenping Cheng
标识
DOI:10.1016/j.eurpolymj.2023.112232
摘要
Antimicrobial resistance is still a major clinical challenge worldwide today and the development of novel antimicrobial agents with high antimicrobial activity and low bacterial resistance is of great importance. In this work, quaternized 2-(dimethylamino) ethylmethacrylates iodonium salt-type monomers with different lengths of pendent alkyl (qDMAEMA(Cx), x = 3, 6 and 8) are synthesized for preparation of a series of cationic porphyrin-based star-shaped (co)polymers by photo-controlled bromine-iodine transformation reversible-deactivation radical polymerization (BIT-RDRP). Especially, qDMAEMA(Cx) not only acts as a monomer but also can be used as an intrinsic catalyst for the BIT-RDRP. In addition, effects of alkyl chain length (x), degree of polymerization and hydrophilic-hydrophobic balance (H.L.B.) on the antibacterial activity of the prepared (co)polymers are investigated. The resulting zinc ion coordinated copolymers [email protected](qDMAEMA(C8)20-co-PEGMA35) (denoted as [email protected]) exhibits good water solubility and is able to be absorbed effectively on the surfaces of bacteria, exhibiting excellent photodynamic inhibition activity against both S. aureus and E. coli under irradiation with 570 nm light source according to the coated plate experiments. The minimum bactericidal concentration (MBC) of [email protected] against S. aureus and E. coli are 1.5 and 2.0 μM, respectively, in the presence of light. Meanwhile, [email protected] shows quite low cytotoxicity and satisfying photolysis ability at working concentrations, displaying promising biological application prospects.
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