生物医学工程
生物相容性
材料科学
体内
心功能曲线
人工心脏
心脏病学
心力衰竭
医学
生物
生物技术
冶金
作者
Jun Li,Timothy A. Hacker,Hao Wu,Yin Long,Fan Yang,Dalong Ni,Allison Rodgers,Weibo Cai,Xudong Wang
出处
期刊:Nano Energy
[Elsevier]
日期:2021-12-01
卷期号:90: 106507-106507
被引量:19
标识
DOI:10.1016/j.nanoen.2021.106507
摘要
Implantable nanogenerators (i-NG) provide power to cardiovascular implantable electronic devices (CIEDs) by harvesting biomechanical energy locally eliminating the need for batteries. However, its long-term operation and biological influences on the heart have not been tested. Here, we evaluate a soft and flexible i-NG system engineered for long-term in vivo cardiac implantation. It consisted of i-NG, leads, and receivers, and was implanted on the epicardium of swine hearts for 2 months. The i-NG system generated electric current throughout the testing period. Biocompatibility and biosafety were established based on normal blood and serum test results and no tissue reactions. Heart function was unchanged over the testing period as validated by normal electrocardiogram (ECG), transthoracic ultrasound, and invasive cardiac functional measures. This research demonstrates the safety, long term operation and therefore the feasibility of using i-NGs to power the next generation CIEDs.
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