机械转化
细胞内
PI3K/AKT/mTOR通路
细胞生物学
神经科学
信号转导
磷脂酰肌醇
生物
作者
Mickaël Di-Luoffo,Zacchari Ben Meriem,Pauline Lefebvre,Morgan Delarue,Julie Guillermet-Guibert
标识
DOI:10.1016/j.tibs.2021.05.005
摘要
Mammalian cells integrate different types of stimuli that govern their fate. These stimuli encompass biochemical as well as biomechanical cues (shear, tensile, and compressive stresses) that are usually studied separately. The phosphatidylinositol 3-kinase (PI3K) enzymes, producing signaling phosphoinositides at plasma and intracellular membranes, are key in intracellular signaling and vesicular trafficking pathways. Recent evidence in cancer research demonstrates that these enzymes are essential in mechanotransduction. Despite this, the importance of the integration of biomechanical cues and PI3K-driven biochemical signals is underestimated. In this opinion article, we make the hypothesis that modeling of biomechanical cues is critical to understand PI3K oncogenicity. We also identify known/missing knowledge in terms of isoform specificity and molecular pathways of activation, knowledge that is needed for clinical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI