镉
Mercury(编程语言)
脾脏
铬
苏木精
曙红
H&E染色
重金属
化学
染色
生理学
环境化学
毒理
病理
内科学
医学
生物
有机化学
程序设计语言
计算机科学
作者
Chantelle Venter,Anel Olivier,Helena Taute,Hester Magdalena Oberholzer
标识
DOI:10.1080/10934529.2020.1756158
摘要
The mining sector in South Africa is expected to be the fifth largest in the world. Both mining and transport are the most common reasons for an increased risk of human exposure to heavy metal contamination in South Africa. Due to increasing amounts of metals in the environment, this study identified three metals cadmium, chromium and mercury based on the risk of exposure in South Africa. The aim of this study was to investigate the changes in the morphology of the spleen tissue of male Sprague-Dawley rats exposed to these metals alone and in combination by using light microscopy. Forty eight animals in eight experimental groups were exposed, via oral gavage, to these metals at 1000× the World Health Organization's acceptable water limits of each respective metal, alone and in combination, for 28 days. Changes in the histological structure of the spleen were observed using haematoxylin and eosin and picrosirius red staining. Necrosis was observed in all the groups, with the severity varying between the different exposure groups, alone or in combination. Fibrosis in the spleen tissue was only seen in the experimental groups exposed to cadmium and mercury respectively, as well as in the combination of cadmium and mercury.
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