微泡
细胞生物学
脂肪组织
干细胞
外体
再生(生物学)
生物
化学
细胞生长
分子生物学
小RNA
人体皮肤
基因
生物化学
遗传学
作者
Eun Wha Choi,Min Koo Seo,Eun Young Woo,Suk Hyung Kim,Eun Joo Park,Sue Kim
摘要
Abstract This study was undertaken to evaluate whether exosomes from human adipose‐derived stem cells (ASC‐exo) can stimulate the regeneration of human dermal fibroblasts (HDFs). Immunoblotting and FACS analyses showed that ASC‐exo was positive for exosome markers. Fluorescence tracking revealed that the contents of ASC‐exo were transferred into the HDFs. ASC‐exo treatment also stimulated the proliferation and migration of HDFs in a dose‐dependent manner. Similarly, the expression levels of genes involved in skin cell proliferation were increased by ASC‐exo. Microarray analysis showed an enrichment of microRNAs that have regenerative function. We suggest that the ASC‐exo can stimulate skin cell proliferation.
科研通智能强力驱动
Strongly Powered by AbleSci AI