生物
热休克蛋白
抗原呈递
细胞生物学
抗原
免疫系统
获得性免疫系统
先天免疫系统
抗原提呈细胞
抗原处理
免疫学
T细胞
生物化学
基因
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2002-04-01
卷期号:20 (1): 395-425
被引量:802
标识
DOI:10.1146/annurev.immunol.20.100301.064801
摘要
Heat shock proteins are abundant soluble intracellular proteins, present in all cells. Members of the heat shock protein family bind peptides including antigenic peptides generated within cells. Heat shock proteins also interact with antigen presenting cells through CD91 and other receptors, eliciting a cascade of events including re-presentation of heat shock protein-chaperoned peptides by MHC, translocation of NF kappa B into the nuclei and maturation of dendritic cells. These consequences point to a key role of heat shock proteins in fundamental immunological phenomena such as activation of antigen presenting cells, indirect presentation (or cross-priming), and chaperoning of peptides during antigen presentation. Heat shock proteins appear to have been involved in innate immune responses since the emergence of phagocytes in early multicellular organisms and to have been commandeered for adaptive immune responses with the advent of specificity. These properties of heat shock proteins also allow them to be used for immunotherapy of cancers and infections in novel ways.
科研通智能强力驱动
Strongly Powered by AbleSci AI