Pancreatic islets in bed with microvasculature—companions for life

In Cell Stem Cell, Aghazadeh et al.1Aghazadeh Y. Poon F. Sarangi F. Wong F.T.M. Khan S.T. Sun X. Hatkar R. Cox B.J. Nunes S.S. Nostro M.C. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models.Cell Stem Cell. 2021; (S1934-5909(21)00338-6)https://doi.org/10.1016/j.stem.2021.08.001Abstract Full Text Full Text PDF PubMed Scopus (19) Google Scholar show that human embryonic stem cell-derived pancreatic progenitors can reverse hyperglycemia for several weeks in streptozotocin-induced diabetic mice when co-transplanted with microvessel fragments into the subcutaneous space.