转运蛋白
小胶质细胞
神经炎症
医学
纹状体
神经科学
单胺氧化酶
药理学
化学
多巴胺
内科学
生物化学
炎症
生物
酶
作者
Vidya Narayanaswami,Junchao Tong,Christin Schifani,Peter Bloomfield,Kenneth Dahl,Neil Vasdev
出处
期刊:Pet Clinics
[Elsevier]
日期:2021-04-01
卷期号:16 (2): 233-247
被引量:12
标识
DOI:10.1016/j.cpet.2020.12.003
摘要
Discovery of novel PET radiotracers targeting neuroinflammation (microglia and astrocytes) is actively pursued. Employing a lipopolysaccharide (LPS) rat model, this longitudinal study evaluated the translocator protein 18-kDa radiotracer [18F]FEPPA (primarily microglia) and monoamine oxidase B radiotracers [11C]L-deprenyl and [11C]SL25.1188 (astrocytes preferred). Increased [18F]FEPPA binding peaked at 1 week in LPS-injected striatum whereas increased lazabemide-sensitive [11C]L-deprenyl binding developed later. No increase in radiotracer uptake was observed for [11C]SL25.1188. The unilateral intrastriatal LPS rat model may serve as a useful tool for benchmarking PET tracers targeted toward distinct phases of neuroinflammatory reactions involving both microglia and astrocytes.
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