顺序装配
图像拼接
基因组
计算机科学
DNA测序
计算生物学
参考基因组
生物
DNA
遗传学
基因
人工智能
转录组
基因表达
作者
Robert Vaser,Mile Šikić
标识
DOI:10.1038/s43588-021-00073-4
摘要
Whole genome sequencing technologies are unable to invariably read DNA molecules intact, a shortcoming that assemblers try to resolve by stitching the obtained fragments back together. Here, we present methods for the improvement of de novo genome assembly from erroneous long reads incorporated into a tool called Raven. Raven maintains similar performance for various genomes and has accuracy on par with other assemblers that support third-generation sequencing data. It is one of the fastest options while having the lowest memory consumption on the majority of benchmarked datasets.
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