whose myeloma is refractory to treatment might still recover their renal function.Moreover, cyclized peptides such as the one described can also help patients with monoclonal gammopathy-related kidney diseases.Many of these patients have nonmalignant lymphoproliferative or plasma cell disorder that would not require treatment if not for the renal complication (10).Therapeutic strategies that target the monoclonal protein rather than the plasma cell are extremely attractive because they would avoid the use of toxic chemotherapy in those patients who do not have a malignancy condition.This strategy could be quite useful in patients with AL amyloidosis who may be too frail to go through chemotherapy.The potential treatment opportunities of this concept represent new and less toxic treatments for the entire range of plasma cell diseases.