Effect of Albumin Concentration and Colloid Osmotic Pressure on Albumin Synthesis in the Perfused Rat Liver

Abstract D ich , J., S. E. H ansen and H. I. D. T hieden . Effect of albumin concentration and colloid osmotic pressure on albumin synthesis in the perfused rat liver. Acta physiol. scand. 1973. 89. 352–358. The effect of the albumin concentration and the colloid osmotic pressure on the rate of albumin synthesis was investigated in the perfused rat liver. The albumin concentration and the colloid osmotic pressure were changed independently. With the same concentration of albumin the rate of albumin synthesis decreased 20 to 30 per cent when the colloid osmotic pressure was increased by addition of gammaglobulin. It is concluded that the rate of albumin synthesis may be regulated by the colloid osmotic pressure. The albumin concentration seems to play a role in regulation only through the contribution to the colloid osmotic pressure.