Etiologies and Outcomes Following Duodenal Perforation in Acute Peritonitis: A Systematic Review

Duodenal perforation often presents as an acute onset of abdominal pain and potential complications such as systemic infection, multiple organ system failure, and even death. It can result from various causes, including peptic ulcer disease (PUD), trauma, malignancies, and infections. Prompt diagnosis and timely intervention are critical for better outcomes, though mortality can be high, particularly in delayed cases. This systematic review aims to synthesize available literature on the etiologies and outcomes associated with duodenal perforation presenting as acute peritonitis, offering a comprehensive overview for guiding effective management strategies. A systematic search was conducted across electronic databases including PubMed, CINAHL, and Google Scholar to identify relevant studies published up to August 2024. Inclusion criteria comprised observational studies, case reports, and case series on duodenal perforation in acute peritonitis. Review articles and non-English language studies were excluded. Two reviewers independently performed data extraction with the opinion of a third reviewer to resolve controversies. Information was gathered on study characteristics, patient demographics, etiology, treatment, and outcomes. A total of 18 studies with 536 participants were included, encompassing a diverse patient population. The primary etiologies identified were PUD, trauma, foreign body, and iatrogenic causes. Treatment approaches ranged from conservative management to surgical interventions, with outcomes varying based on the underlying cause and timeliness of treatment. Postoperative complications were significant, including wound infections, anastomotic leaks, and, in severe cases, multiorgan failure. Mortality was largely associated with delayed intervention. Despite advancements in surgical techniques, the condition still carries a significant risk of complications and mortality, underscoring the need for timely and effective medical care. Future research should focus on developing standardized guidelines to optimize the management of duodenal perforations and reduce associated morbidity and mortality.