Heart–liver axis implications of the new steatotic liver disease nomenclature

The intricate relationship between cardiovascular and hepatic health has been dubbed the heart–liver axis and has historically centred on non-alcoholic fatty liver disease (NAFLD). 1 Targher G Day CP Bonora E Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010; 363: 1341-1350 Crossref PubMed Scopus (1513) Google Scholar Given its association with metabolic disorders (eg, obesity and insulin resistance) and cardiovascular disease risks, NAFLD bridged a gap between coexisting cardiac and hepatic pathologies. However, our understanding of causal overlaps between the pathologies and the need for nuanced nomenclatures has changed.