Nanoscience brings together the focal scientific issues in the nanoscale in the fields of chemistry, physics, energy, environment and materials, etc., and has gradually become a cutting-edge research field that integrates intersections, leads, and supports. The development of nanomaterials has profoundly influenced the progress of modern science, and atomic materials will be a new driving force for the development of nanomaterials in the coming decades. The design of nano-atomic interface structural materials will become the next round of subversive research hotspot. This will help accelerate the process of “carbon neutrality,” improve the living environment of human beings, and contribute to the sustainable development of energy science. In this chapter, the future outlooks of nanomaterials and sub–nanomaterials (including atomic-structured materials) are concisely analyzed and summarized.