Nontargeted detection and recognition of adulterants in milk powder using Raman imaging and neural networks

Raman imaging technology combined with targeted chemometrics can play a vital role in the rapid detection of milk powder adulteration, which threatens the lives of infants and other people. However, these methods always suffer from a narrow detection range. Nontargeted methods show a broader detection range but cannot recognize adulterants. Here, a novel nontargeted chemometric method, named as the adversarial discrimination neural network (ADNN), is proposed to detect and recognize adulterants simultaneously. The method comprises building a tight boundary in the feature space of Raman images to discriminate milk powder samples from the majority of adulterated cases. Then a first-order partial derivative of the ADNN is calculated to recognize different adulterants through a local approximation strategy. A validation set containing samples adulterated with various adulterants at concentrations ranging from 0.3% to 1.5% w/w was provided to challenge the proposed method. The validated detection accuracy of the proposed method for authentic and adulterated samples was 99.9% and 99.7% and the adulterants were recognized correctly. The ADNN-Raman represents a novel nontargeted and end-to-end tool for detecting and recognizing adulterants in milk powder simultaneously, providing new insights into nontargeted chemometric analysis.