Research Progress on Enantioselective Desymmetrization Reactions Involving Metal Carbenes

Metal carbenes have been widely applied in organic synthesis, and they can undergo a variety of chemical transformations due to their versatile reactivities.In this review, the desymmetrization of C-H insertion reaction, Buchner reaction, Si-H insertion reaction and B-H insertion reaction involving metal carbenes is introduced according to the different reaction types of metal carbenes.Under the catalysis of chiral rhodium, ruthenium and copper catalysts, chiral carbocycles, heterocycles, organosilicons and organoborons can be obtained with high enantioselectivity, which greatly enriches the development of asymmetric synthetic chemistry.