RIP3 as a diagnostic and severity marker for Stevens-Johnson syndrome and toxic epidermal necrolysis

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases.1 Medication and infections, including those caused by Mycoplasma pneumoniae and cytomegalovirus, are common causes.1 Both diseases are characterized by skin detachment, differentiating them from other generalized skin eruptions such as maculopapular exanthema and erythema multiforme (EM). However, clinical manifestations of SJS/TEN are occasionally undistinguishable from those of early EM because blisters or mucous lesions are mild.