适体
受体
生物分子
化学
生物物理学
纳米颗粒
分子
树枝状大分子
配体(生物化学)
方向性
纳米技术
材料科学
生物化学
生物
遗传学
有机化学
作者
Liang Guo,Yueyue Zhang,Yue Wang,Mo Xie,Jiangbing Dai,Zhi Qu,Mo Zhou,Shuting Cao,Jiye Shi,Lihua Wang,Xiaolei Zuo,Chunhai Fan,Jiang Li
标识
DOI:10.1002/anie.202117168
摘要
Multivalent interactions of biomolecules play pivotal roles in physiological and pathological settings. Whereas the directionality of the interactions is crucial, the state-of-the-art synthetic multivalent ligand-receptor systems generally lack programmable approaches for orthogonal directionality. Here, we report the design of programmable atom-like nanoparticles (aptPANs) to direct multivalent aptamer-receptor binding on the cell interface. The positions of the aptamer motifs can be prescribed on tetrahedral DNA frameworks to realize atom-like orthogonal valence and direction, enabling the construction of multivalent molecules with fixed aptamer copy numbers but different directionality. These directional-yet-flexible aptPAN molecules exhibit the adaptability to the receptor distribution on cell surfaces. We demonstrate the high-affinity tumor cell binding with a linear aptPAN oligomer (≈13-fold improved compared to free aptamers), which leads to ≈50 % suppression of cell growth.
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