医学
多发性硬化
髓鞘少突胶质细胞糖蛋白
临床孤立综合征
髓鞘
神经科学
少突胶质细胞
髓鞘相关糖蛋白
脱髓鞘病
内科学
免疫学
心理学
中枢神经系统
实验性自身免疫性脑脊髓炎
作者
Eva-Maria Wendel,Andrea Bertolini,Lampros Kousoulos,Markus Rauchenzauner,Kathrin Schanda,Andreas Wegener-Panzer,Matthias Baumann,Markus Reindl,Markus Otto,Kevin Rostásy
标识
DOI:10.1177/13524585221081090
摘要
To assess the diagnostic and prognostic potential of serum neurofilament light chain (sNfL) in children with first acquired demyelinating syndrome (ADS).We selected 129 children with first ADS including 19 children with myelin oligodendrocyte glycoprotein (MOG)-antibody associated disease (MOGAD), 36 MOG/AQP4-seronegative ADS, and 74 with multiple sclerosis (MS) from the BIOMARKER study cohort. All children had a complete set of clinical, radiological, laboratory data and serum for NfL measurement using a highly sensitive digital ELISA (SIMOA). A control group of 35 children with non-inflammatory neurological diseases was included. sNfL levels were compared across patient groups according to clinical, laboratory, neuroradiological features and outcome after 2 years.sNfL levels were significantly increased in MOGAD, seronegative ADS and MS compared to controls (p-value < 0.001), in particular in children with an acute disseminated encephalomyelitis (ADEM)-like magnetic resonance imaging (MRI) pattern (p < 0.001) or longitudinally extensive myelitis (p < 0.01). In pediatric MS, elevated sNfL levels were significantly associated with higher numbers of cerebral (p < 0.001) and presence of spinal (p < 0.05) MRI lesions at baseline and predicted a higher number of relapses (p < 0.05).sNfL levels are significantly elevated in all three studied pediatric ADS subtypes indicating neuroaxonal injury. In pediatric MS high levels of sNfL are associated with risk factors for disease progression.
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