贝加普顿
斑马鱼
体内
活性氧
炎症
化学
一氧化氮
细胞凋亡
生物
药理学
细胞生物学
生物化学
免疫学
补骨脂素
DNA
有机化学
生物技术
基因
作者
Yi Yuan Yang,Kangdi Zheng,Wenjie Mei,Yandong Wang,Chuqin Yu,Bingkun Yu,Shanbin Deng,Jinhua Hu
标识
DOI:10.1016/j.bbrc.2018.01.071
摘要
Bergapten (5-methoxypsoralen), a coumarin-derivate compound isolated from Ficus hirta roots, was evaluated for its anti-inflammatory and proresolution activities in a tail-cutting-induced zebrafish larvae model. Bergapten was evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(corola: eGFP)” to visualize the effects of the recruitment and clearance of neutrophils and macrophages at the injury site. We found that bergapten significantly suppressed the recruitment of neutrophils and macrophages toward the injury site, as well as promoted the clearance of neutrophils and macrophages from the wound site. We also investigated the reactive oxygen species (ROS) and nitric oxide (NO) level of bergapten in a tail-cutting-induced inflammation zebrafish model. The Results revealed that bergapten effectively inhibited the tail-cutting-induced production of ROS and NO in zebrafish larvae. This study reported for the first time the potential anti-inflammatory and proresolution activities of bergapten in an in vivo zebrafish model, suggesting that bergapten may be a potential candidate for inflammation therapy.
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