期刊:Science [American Association for the Advancement of Science (AAAS)] 日期:2017-08-24卷期号:357 (6353): 768.3-768
标识
DOI:10.1126/science.357.6353.768-c
摘要
Immunology
CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal T cells believed to take part in a variety of immune responses, including oral tolerance. These cells are absent in germ-free mice, but the mechanisms driving their development are unclear. Cervantes-Barragan et al. found that a particular species of probiotic bacteria, Lactobacillus reuteri , induces DP IELs. This does not occur by stimulating the immune system directly. Instead, L. reuteri generates a specific derivative of dietary tryptophan that promotes differentiation of DP IEL precursors. These findings underscore the delicate interplay between benign bacteria, diet, and gut health.
Science , this issue p. [806][1]
[1]: /lookup/doi/10.1126/science.aah5825