免疫系统
生物
有机体
鉴定(生物学)
转录组
计算生物学
核糖核酸
细胞
单细胞测序
免疫学
遗传学
表型
基因
基因表达
生态学
外显子组测序
作者
Haide Chen,Fang Ye,Guoji Guo
标识
DOI:10.1038/s41423-019-0214-4
摘要
The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain homeostasis. Identifying heterogeneity of immune cells is the key to understanding the immune system. Advanced single-cell RNA sequencing (scRNA-seq) technologies are revolutionizing our ability to study immunology. By measuring transcriptomes at the single-cell level, scRNA-seq enables identification of cellular heterogeneity in far greater detail than conventional methods. In this review, we introduce the existing scRNA-seq technologies and present their strengths and weaknesses. We also discuss potential applications and future innovations of scRNA-seq in immunology.
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