Advances in studies on drug carrier poly lactic-co-glycolic acid in controlled release microspheres

Poly lactic-co-glycolic acid(PLGA) is a biodegradable polymer used to fabricate devices for drug delivery and tissue engineering scaffolds,and has been approved by the FDA in US.Its application in fabrication of devices for drug delivery,including small molecular drug,protein and other macromolecules(DNA,RNA or peptides) has become a hot spot of study in recent two decades for its good biodegradability,and biocompatibility.Most studies focused on controlled release microspheres of vaccine,hormone,antibiotics,anticancer agent,neurotrophic active substances,etc.This paper describes some studies on these controlled release microspheres in recent five years.