骨重建
骨桥蛋白
医学
N-末端末端肽
内科学
骨钙素
内分泌学
骨硬化
全身性肥大细胞增多症
类胰蛋白酶
促炎细胞因子
细胞因子
骨保护素
病理
骨髓
免疫学
碱性磷酸酶
化学
炎症
肥大细胞
受体
酶
激活剂(遗传学)
生物化学
作者
Tiago Azenha Rama,Ana Filipa Henriques,Almudena Matito,Maria Jara-Acevedo,Carolina Caldas,Andrea Mayado,Javier I. Muñoz-González,André Moreira,João Cavaleiro-Rufo,Andrés García-Montero,Alberto Órfão,Laura Sanchez-Muñoz,Iván Álvarez-Twose
标识
DOI:10.1016/j.jaip.2023.02.007
摘要
Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown.To investigate the potential association between cytokine and bone remodeling markers with bone disease in SM, aiming at identifying biomarker profiles associated with bone loss and/or osteosclerosis.A total of 120 adult patients with SM, divided into 3 age and sex-matched groups according to their bone status were studied: (1) healthy bone (n = 46), (2) significant bone loss (n = 47), and (3) diffuse bone sclerosis (n = 27). Plasma levels of cytokines and serum baseline tryptase and bone turnover marker levels were measured at diagnosis.Bone loss was associated with significantly higher levels of serum baseline tryptase (P = .01), IFN-γ (P = .05), IL-1β (P = .05), and IL-6 (P = .05) versus those found in patients with healthy bone. In contrast, patients with diffuse bone sclerosis showed significantly higher levels of serum baseline tryptase (P < .001), C-terminal telopeptide (P < .001), amino-terminal propeptide of type I procollagen (P < .001), osteocalcin (P < .001), bone alkaline phosphatase (P < .001), osteopontin (P < .01), and the C-C Motif Chemokine Ligand 5/RANTES chemokine (P = .01), together with lower IFN-γ (P = .03) and RANK-ligand (P = .04) plasma levels versus healthy bone cases.SM with bone mass loss is associated with a proinflammatory cytokine profile in plasma, whereas diffuse bone sclerosis shows increased serum/plasma levels of biomarkers related to bone formation and turnover, in association with an immunosuppressive cytokine secretion profile.
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