透明质酸
胶水
外科
伤口愈合
医学
手术伤口
粘附
自愈水凝胶
化学
材料科学
高分子化学
复合材料
解剖
有机化学
作者
Zimu Li,Li Yang,Dan Zhang,Wenyan Wang,Qili Huang,Qingyun Liu,Kexin Shi,Ying‐Hui Yu,Nansha Gao,Hongzhong Chen,Shiwei Jiang,Zhongjian Xie,Xiaowei Zeng
标识
DOI:10.1016/j.jcis.2023.07.154
摘要
Currently, clinical tumor resection is faced with two options: open and minimally invasive surgery. Open surgery is easy to completely remove the lesion but is prone to infection, while minimally invasive surgery recovers faster but may cause tumor recurrence. To fill the shortcomings of the two surgical modes and make the choice for tumor resection more effortlessly, we developed a postoperative black phosphorus-Ag nanocomposites-loaded dopamine-modified hyaluronic acid-Pluronic® F127 (BP-Ag@HA-DA-Plu) hydrogel implantation system that can prevent tumor recurrence and wound infection simultaneously. Experiments have shown that the hydrogel system combined with 808 nm near-infrared (NIR) irradiation has excellent anti-tumor, antibacterial, and wound healing abilities. Additionally, unlike existing surgical hydrogel products that require inconvenient in-situ cross-linking, the BP-Ag@HA-DA-Plu hydrogel system offers “plug-and-play” functionality during surgery due to its thermo-responsiveness, injectability, and adhesion, thereby greatly improving the efficiency of surgery.
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