姜黄素
伤口愈合
生物利用度
溶解度
血管生成
化学
蛋白酶
药理学
生物医学工程
纳米技术
材料科学
生物化学
有机化学
癌症研究
酶
医学
外科
作者
Anjana Sharma,Vineeta Panwar,Navita Salaria,Deepa Ghosh
出处
期刊:Biomaterials advances
日期:2022-08-01
卷期号:139: 212978-212978
被引量:13
标识
DOI:10.1016/j.bioadv.2022.212978
摘要
The pharmacological effects of curcumin can be ascribed to its dose–dependent activity. Therapeutic application of curcumin is hindered by its poor solubility and low bioavailability. Carbon dots are gaining attention in biomedical applications in view of their unique photo-physical properties. Some carbon dots derived from bioactive molecules have shown superior activity than the parent compound. With an aim to address the limitations of curcumin, herein we compared the wound healing activity of curcumin-derived carbon dots (CurCD) with curcumin. The improved solubility and stability of CurCD, combined with its superior proliferative, proangiogenic and anti-bacterial activity suggested that CurCD would be more beneficial than curcumin in wound healing. To enable the sustained release of CurCD at the wound site, a protease-responsive hydrogel (GHCD) was prepared with CurCD acting as a cross-linker. A comparative study using a skin excision model revealed that GHCD supported faster wound closure with improved angiogenesis and complete restoration of the epithelium. Apart from the establishment of CurCD as a wound healing agent, the study provides a novel carbon dot based approach for molecules with limitations of solubility and bioavailability.
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