G-四倍体
端粒
DNA
咔咯
表面等离子共振
化学
聚合酶
计算生物学
基因
立体化学
组合化学
生物
生物化学
纳米技术
光化学
材料科学
纳米颗粒
作者
Hao Ma,Ming Zhang,Dan Zhang,Rong Huang,Yang Zhao,Hao Yang,Yijing Liu,Xiaocheng Weng,Yangyang Zhou,Ming‐Gang Deng,Liang Xu,Xiang Zhou
标识
DOI:10.1002/asia.200900270
摘要
Abstract G‐quadruplex DNA plays an important role in the potential therapeutic target for the design and development of anticancer drugs. As various G‐quadruplex sequences in the promoter regions or telomeres can form different secondary structural modes and display a diversity of biology functions, variant G‐quadruplex interactive agents may be necessary to cure different disease by differentiating variant types of G‐quadruplexes. We synthesize five cationic methylpyridylium corroles and compare the interactions of corroles with different types of G‐quadruplexes such as cmyc, htelo, and bcl2 by using surface plasmon resonance. Because of the importance of human telomere G‐quadruplex DNA, we focus on the biological properties of the interactions between human telomere G‐quadruplex DNA and corrole isomers using CD, T m , PCR‐stop (PCR= polymerase chain reaction), and polymerase‐stop assay, which demonstrate the excellent ability of the corrole to induce and stabilize the G‐quadruplex. This study provides the first experimental insight into how selectivity might be achieved for different G‐quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy.
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