黑皮素
瘦素
肥胖
人类肥胖
黑素皮质素
功能(生物学)
医学
生物信息学
生物
内分泌学
遗传学
激素
出处
期刊:KARGER eBooks
[S. Karger AG]
日期:2008-01-01
卷期号:: 1-11
被引量:73
摘要
We and others have identified several single gene defects that disrupt the molecules in the leptinmelanocortin pathway causing severe obesity in humans. In this review, we consider these human monogenic obesity syndromes and discuss how far the characterisation of these patients has informed our understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function.
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