生物
蛋白质组
拟南芥
计算生物学
蛋白质组学
线粒体
功能(生物学)
线粒体融合
线粒体DNA
细胞生物学
遗传学
基因
突变体
作者
Joshua L. Heazlewood,Julian Tonti-Filippini,Alexander M. Gout,David A. Day,James Whelan,A. Harvey Millar
出处
期刊:The Plant Cell
[Oxford University Press]
日期:2004-01-01
卷期号:16 (1): 241-256
被引量:565
摘要
A novel insight into Arabidopsis mitochondrial function was revealed from a large experimental proteome derived by liquid chromatography-tandem mass spectrometry. Within the experimental set of 416 identified proteins, a significant number of low-abundance proteins involved in DNA synthesis, transcriptional regulation, protein complex assembly, and cellular signaling were discovered. Nearly 20% of the experimentally identified proteins are of unknown function, suggesting a wealth of undiscovered mitochondrial functions in plants. Only approximately half of the experimental set is predicted to be mitochondrial by targeting prediction programs, allowing an assessment of the benefits and limitations of these programs in determining plant mitochondrial proteomes. Maps of putative orthology networks between yeast, human, and Arabidopsis mitochondrial proteomes and the Rickettsia prowazekii proteome provide detailed insights into the divergence of the plant mitochondrial proteome from those of other eukaryotes. These show a clear set of putative cross-species orthologs in the core metabolic functions of mitochondria, whereas considerable diversity exists in many signaling and regulatory functions.
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