Prostatic Zinc and Prostate Specific Antigen: An Experimental Evaluation of Their Combined Diagnostic Value

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Dec 2003Prostatic Zinc and Prostate Specific Antigen: An Experimental Evaluation of Their Combined Diagnostic Valueis corrected byRE: PROSTATIC ZINC AND PROSTATE SPECIFIC ANTIGEN: AN EXPERIMENTAL EVALUATION OF THEIR COMBINED DIAGNOSTIC VALUE D. VARTSKY, S. SHILSTEIN, A. BERCOVICH, M. HUSZAR, A. BRESKIN, R. CHECHIK, S. KOROTINSKY, S.D. MALNICK, and E. MORIEL D. VARTSKYD. VARTSKY , S. SHILSTEINS. SHILSTEIN , A. BERCOVICHA. BERCOVICH , M. HUSZARM. HUSZAR , A. BRESKINA. BRESKIN , R. CHECHIKR. CHECHIK , S. KOROTINSKYS. KOROTINSKY , S.D. MALNICKS.D. MALNICK , and E. MORIELE. MORIEL View All Author Informationhttps://doi.org/10.1097/01.ju.0000095795.86327.b8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In cancer affected prostate cells lose the ability to concentrate zinc, resulting in a substantial decrease in Zn in the prostate. We investigated the possibility of using prostatic zinc combined with prostate specific antigen (PSA) as a novel tool for the reliable diagnosis of prostate cancer. Materials and Methods: Using the x-ray fluorescence method the Zn concentration was determined in vitro in prostate samples extracted by surgery from 28 patients. Clinical records included age, serum PSA, sextant prostate needle biopsy, previous medical therapy, surgical procedure and histological findings. Results: A new relationship was found between Zn in prostate tissue and PSA in blood, which allows improved separation between prostate cancer and benign prostate hyperplasia, and might have a significant impact on the reliable diagnosis of prostate cancer. Conclusions: Zn concentration is not uniform even in the same anatomical region of the prostate, so that a number of measurements at various locations are required for a diagnostic procedure. The most interesting finding in this study is the relationship between Zn concentration and PSA. A combination of these parameters represents a significant improvement on the diagnostic value of each of them separately and provides a powerful tool for more accurate diagnosis. Although the method may be applied in vitro on biopsy samples, our study underlines the importance of developing a facility for in vivo Zn determination in the prostate. References 1 : Diagnosis and staging of prostate cancer. In: . Philadelphia: W. B. Saunders Co.1998: 2519. chapt. 83. Google Scholar 2 : Clinical utility of measurements of free and total prostate-specific antigen (PSA): a review. Prostate1996; 7: 64. Google Scholar 3 : Use of percentage of free prostate-specific antigen to identify men at high risk of prostate cancer when PSA levels are 2.51 to 4 ng/mL and digital examination is not suspicious for prostate cancer: an alternative model. Urology1999; 54: 220. Google Scholar 4 : The male genital tract. In: Robbins Pathologic Basis of Disease. Philadelphia: W. B. Saunders Co.1999: 1029. Google Scholar 5 : Zinc and magnesium in human prostate gland: normal hyperplastic, and neoplastic. Cancer Res1967; 27: 1348. Google Scholar 6 : Concepts of citrate production and secretion by prostate. 1. Metabolic relationships. Prostate1991; 18: 25. Google Scholar 7 : Zinc causes a shift toward citrate at equilibrium of the m-aconitase reaction of the prostate mitochondria. J Inorg Biochem2000; 78: 161. Google Scholar 8 : Zinc and cadmium concentrations in whole tissue and separated epithelium and stroma from human benign prostatic hypertrophic glands. Prostate1985; 6: 177. Google Scholar 9 : Atomic absorption spectrophotometric determination of zinc in the prostate. Invest Urol1969; 6: 345. Google Scholar 10 : Distribution and concentration of zinc in the subcellular fractions of benign hyperplastic and malignant neoplastic human prostate. Exp Mol Pathol1973; 19: 139. Google Scholar 11 : Cancer of the prostate: early diagnosis by zinc and hormone analysis. Br J Cancer1979; 39: 700. Google Scholar 12 : Zinc and cadmium concentrations in indigenous blacks with normal, hypertrophic, and malignant prostate. Cancer1989; 63: 1388. Google Scholar 13 : Zinc and cadmium concentration in prostatic carcinoma of different histological grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH). Urol Res1982; 10: 301. Google Scholar 14 : Zinc in the human prostate gland: normal, hyperplastic and cancerous. Int Urol Nephrol1997; 29: 565. Google Scholar 15 : Novel role of zinc in the regulation of citrate metabolism and its implications in prostate cancer. Prostate1998; 35: 285. Google Scholar 16 : Histologic grading and clinical staging of prostatic carcinoma. In: Urologic Pathology: The Prostate. Edited by . Philadelphia: Lea & Febiger1977: 171. part II. Google Scholar 17 Shilstein, S. Sh. Breskin, A., Chechik, R., Feldman, G., Vartsky, D.: In-vivo determination of prostatic Zn: phantom feasibility study. Unpublished data. Google Scholar From the Soreq NRC (DV), Yavne and Department of Particle Physics, Weizmann Institute of Science (SS, AB, AB, RC, SK) and Kaplan Medical Center (AB, MH, SK, SDM, EM), Rehovot, Israel© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsRelated articlesJournal of Urology9 Nov 2018RE: PROSTATIC ZINC AND PROSTATE SPECIFIC ANTIGEN: AN EXPERIMENTAL EVALUATION OF THEIR COMBINED DIAGNOSTIC VALUE Volume 170Issue 6December 2003Page: 2258-2262 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsprostate-specific antigenprostatic neoplasmszincprostatespectrometry, x-ray emissionMetricsAuthor Information D. VARTSKY More articles by this author S. SHILSTEIN More articles by this author A. BERCOVICH Financial interest and/or other relationship with Pfizer Pharmaceuticals. More articles by this author M. HUSZAR More articles by this author A. BRESKIN More articles by this author R. CHECHIK More articles by this author S. KOROTINSKY More articles by this author S.D. MALNICK More articles by this author E. MORIEL More articles by this author Expand All Advertisement PDF downloadLoading ...