材料科学
收缩性
聚二甲基硅氧烷
标度系数
脆性
复合材料
灵敏度(控制系统)
图层(电子)
生物医学工程
纳米技术
光电子学
制作
心脏病学
电子工程
医学
替代医学
病理
工程类
作者
Li Wang,Xingyuan Xu,Jun Chen,Weiguang Su,Feng Zhang,Anqing Li,Chao Li,Chonghai Xu,Yu Sun
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-07-22
卷期号:16 (8): 12645-12655
被引量:16
标识
DOI:10.1021/acsnano.2c04260
摘要
Measuring myocardial contractility is of great value in exploring cardiac pathogenesis and quantifying drug efficacy. Among the biosensing platforms developed for detecting the weak contractility of a single layer of cardiomyocytes (CMs), thin brittle metal membrane sensors with microcracks are highly sensitive. However, their poor stability limits the application in long-term measurement. Here, we report a high stability crack sensor fabricated by deposition of a 105 nm thick Ag/Cr with microcracks onto a carbon nanotubes-polydimethylsiloxane (CNT-PDMS) layer. This brittle-tough bilayer crack sensor achieved high sensitivity (gauge factor: 108 241.7), a wide working range (0.01-44%), and high stability (stable period >2 000 000 cycles under the strain caused by a monolayer of CMs). During 14-day continuously monitoring CMs culturing and drug treatment testings, the device demonstrated high sensitivity and stability to record the dynamic change caused by contractility of the CMs.
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