帕尔瓦布明
神经科学
工作记忆
前额叶皮质
加巴能
刺激(心理学)
中间神经元
认知
心理学
生物
抑制性突触后电位
认知心理学
作者
Michael Lagler,A. Tugrul Ozdemir,Sabria Lagoun,Hugo Malagon‐Vina,Zsolt Borhegyi,Romana Hauer,Anna Jelem,Thomas Klausberger
出处
期刊:Neuron
[Elsevier]
日期:2016-09-01
卷期号:91 (6): 1390-1401
被引量:62
标识
DOI:10.1016/j.neuron.2016.08.010
摘要
Summary
Parvalbumin-expressing basket cells tightly control cortical networks and fire remarkably stereotyped during network oscillations and simple behaviors. How can these cells support multifaceted situations with different behavioral options and complex temporal sequences? We recorded from identified parvalbumin-expressing basket cells in prefrontal cortex of freely moving rats performing a multidimensional delayed cue-matching-to-place task, juxtacellularly filled recorded neurons for unequivocal histological identification, and determined their activity during temporally structured task episodes, associative working-memory, and stimulus-guided choice behavior. We show that parvalbumin-expressing basket cells do not fire homogenously, but individual cells were recruited or inhibited during different task episodes. Firing of individual basket cells was correlated with amount of presynaptic VIP (vasoactive intestinal polypeptide)-expressing GABAergic input. Together with subsets of pyramidal neurons, activity of basket cells differentiated for sequential actions and stimulus-guided choice behavior. Thus, interneurons of the same cell type can be recruited into different neuronal ensembles with distinct firing patterns to support multi-layered cognitive computations.
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