医学
结肠镜检查
促动剂
泻药
莫沙比利
肠道准备
内科学
耐受性
胃肠病学
排便
不利影响
癌症
结直肠癌
作者
Yuko Mishima,Yuji Amano,Koichi Okita,Yoshiko Takahashi,Nobuyuki Moriyama,Norihisa Ishimura,Katsuhisa Furuta,Shunji Ishihara,Kyoichi Adachi,Yoshikazu Kinoshita
出处
期刊:Digestion
[S. Karger AG]
日期:2008-01-01
卷期号:77 (3-4): 166-172
被引量:27
摘要
<i>Background and Aim: </i>Colonoscopy plays an important role in the diagnosis and treatment of gastrointestinal illness in both Western countries and Japan. However, preparative bowel cleansing for colonoscopy is frequently troublesome for elderly and/or constipated patients, since they must drink larger volumes of lavage solution for adequate cleansing. We investigated the use of prokinetic agents for improving the efficacy and tolerability of bowel cleansing prior to colonoscopy. <i>Methods:</i> 613 patients were divided into two groups according to oral lavage solution used (polyethylene glycol or magnesium citrate), and were further randomized to receive either vehicle (100 ml water) alone, vehicle with 5 mg mosapride citrate, or vehicle with 50 mg itopride hydrochloride 30 min before administration of lavage solution. Experimental parameters included bowel cleansing quality, times to first defecation and completion of bowel cleansing, and incidence of uncomfortable abdominal symptoms during colonoscopy preparation. <i>Results:</i> Administration of mosapride citrate or itopride hydrochloride prior to oral lavage solution did not significantly improve bowel cleansing quality. However, statistically significantly fewer uncomfortable abdominal symptoms were found in patients who received mosapride citrate or itopride hydrochloride versus vehicle alone. <i>Conclusion: </i>Prokinetic agents effectively decreased the incidence of uncomfortable abdominal symptoms experienced during colonoscopy preparation.
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