Chondroitin sulfate on leukocytes mediates thrombus resolution and organization: an in vivo imaging study

Chondroitin sulfate glycosaminoglycans (CS-GAGs), one of the many factors that regulates inflammation, are found to be crucial in enhancing thrombus resolution and organization during the natural course of DVT. Alteration in CS-GAGs on the cell surface of leukocytes due to ChGn-2, an enzyme that mainly participates in the elongation of CS-GAGs, impacts their capacity to migrate into the thrombus and drive the resolution process.