代谢工程
生化工程
生产(经济)
可持续生产
工业生产
自然(考古学)
生物量(生态学)
可再生资源
可再生能源
生物技术
风险分析(工程)
工程类
化学
业务
生物
生物化学
生态学
经济
凯恩斯经济学
酶
古生物学
宏观经济学
电气工程
作者
Dongsoo Yang,Hyunmin Eun,Cindy Pricilia Surya Prabowo,Sumin Cho,Sang Yup Lee
标识
DOI:10.1016/j.copbio.2022.102760
摘要
Increased awareness of the environmental and health concerns of consuming chemically synthesized products has led to a rising demand for natural products that are greener and more sustainable. Despite their importance, however, industrial-scale production of natural products has been challenging due to the low yield and high cost of the bioprocesses. To cope with this problem, systems metabolic engineering has been employed to efficiently produce natural products from renewable biomass. Here, we review the recent systems metabolic engineering strategies employed for enhanced production of value-added natural products, together with accompanying examples. Particular focus is set on systems-level engineering and cell physiology engineering strategies. Future perspectives are also discussed.
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