流化床
过程分析技术
涂层
颗粒
涂膜
工艺工程
造粒
材料科学
流态化
弹丸
近红外光谱
复合材料
化学工程
纳米技术
废物管理
工程类
光学
物理
生物过程
作者
Ronghua Liu,Lian Li,Wenping Yin,Dongbo Xu,Hengchang Zang
标识
DOI:10.1016/j.ijpharm.2017.07.051
摘要
The fluidized bed granulation and pellets coating technologies are widely used in pharmaceutical industry, because the particles made in a fluidized bed have good flowability, compressibility, and the coating thickness of pellets are homogeneous. With the popularization of process analytical technology (PAT), real-time analysis for critical quality attributes (CQA) was getting more attention. Near-infrared (NIR) spectroscopy, as a PAT tool, could realize the real-time monitoring and control during the granulating and coating processes, which could optimize the manufacturing processes. This article reviewed the application of NIR spectroscopy in CQA (moisture content, particle size and tablet/pellet thickness) monitoring during fluidized bed granulation and coating processes. Through this review, we would like to provide references for realizing automated control and intelligent production in fluidized bed granulation and pellets coating of pharmaceutical industry.
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